The 2021 Toyota Sienna is available as a 4-door, 7-seat passenger van. Starting at $34,460, the 2021 Toyota Sienna LE 8 FWD is powered by a 2.5LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 36-mpg in the city and 36-mpg on the highway. The top of the line 2021ToyotaSiennaXSE 7 AWD , priced at $ 42,760 , is powered by a 2.5LL , 4 - cylinder engine mated to an automatic transmission that returns an EPA estimated 35-mpg in the city and 36-mpg on the highway.