The 2006 Toyota Sienna is available as a 4-door, 7-seat passenger van. Starting at $23,775, the 2006 Toyota Sienna CE FWD Passenger is powered by a 3.3L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway. The top of the line 2006 Toyota Sienna FWD Cargo, priced at $00, is powered by a 3.3L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.