The 2006 Toyota Highlander is available as a 4-door, 5-seat sport utility. Starting at $24,530, the 2006 Toyota Highlander Base w/o 3rd (A4) FWD is powered by a 2.4L , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 27-mpg on the highway. The top of the line 2006ToyotaHighlanderV6 w/o 3rd (A5) AWD , priced at $ 26,990 , is powered by a 3.3L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 24-mpg on the highway.