The 2022 Nissan Titan is available as a 4-door, 5-seat regular side. Starting at $40,580, the 2022 Nissan Titan S 4x2 Crew Cab is powered by a 5.6LL , 8 -cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 21-mpg on the highway. The top of the line 2022NissanTitanSV 4x4 King Cab , priced at $ 47,400 , is powered by a 5.6LL , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 15-mpg in the city and 21-mpg on the highway.