The 2021 Nissan Titan is available as a 4-door, 5-seat regular side. Starting at $39,380, the 2021 Nissan Titan S 4x2 Crew Cab is powered by a 5.6L, 8-cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 21-mpg on the highway. The top of the line 2021 Nissan Titan PRO-4X 4x4 King Cab, priced at $48,170, is powered by a 5.6L, 8-cylinder engine mated to an automatic transmission that returns an EPA estimated 15-mpg in the city and 20-mpg on the highway.