The 2021 Nissan Murano is available as a 4-door, 5-seat sport utility. Starting at $32,810, the 2021 Nissan Murano S FWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 28-mpg on the highway. The top of the line 2021NissanMuranoPlatinum AWD , priced at $ 45,910 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 28-mpg on the highway.