The 2010 Nissan Murano is available as a 4-door, 5-seat sport utility. Starting at $28,340, the 2010 Nissan Murano S FWD is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 23-mpg on the highway. The top of the line 2010NissanMuranoLE AWD , priced at $ 38,710 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 23-mpg on the highway.