The 2021 Mercedes-Benz Sprinter 2500 is available as a 3-door, 2-seat cargo van. Starting at $37,585, the 2021 Mercedes-Benz Sprinter 2500 I4 Sprinter 2500 RWD Cargo 144 WB RWD HD is powered by a 2.0LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated The top of the line 2021Mercedes-BenzSprinter 2500Sprinter 2500 4WD Extended Cargo 170 WB 4WD HD , priced at $ 58,185 , is powered by a 3.0LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated