The 2022 Mercedes-Benz S-Class is available as a 4-door, 5-seat sedan. Starting at $111,100, the 2022 Mercedes-Benz S-Class S 500 is powered by a 3.0LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 30-mpg on the highway. The top of the line 2022Mercedes-BenzS-ClassS 580 , priced at $ 117,700 , is powered by a 4.0LL , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 25-mpg on the highway.
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