The 2020 Mercedes-Benz S-Class is available as a 4-door, 5-seat sedan. Starting at $97,250, the 2020 Mercedes-Benz S-Class S 450 AWD 4MATIC Sedan is powered by a 3.0L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 28-mpg on the highway. The top of the line 2020Mercedes-BenzS-ClassS 560 RWD Cabriolet , priced at $ 138,600 , is powered by a 4.0L , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 17-mpg in the city and 26-mpg on the highway.