The 2012 Mercedes-Benz S-Class is available as a 4-door, 5-seat sedan. Starting at $159,500, the 2012 Mercedes-Benz S-Class S 600 RWD Sedan is powered by a 5.5L , 12 -cylinder engine mated to an automatic transmission that returns an EPA estimated 12-mpg in the city and 19-mpg on the highway. The top of the line 2012Mercedes-BenzS-ClassS 350 BlueTEC AWD 4MATIC , priced at $ 92,550 , is powered by a 3.0L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 31-mpg on the highway.