The 2006 Mercedes-Benz S-Class is available as a 4-door, 5-seat sedan. Starting at $77,250, the 2006 Mercedes-Benz S-Class RWD Sedan is powered by a 4.3L, 8-cylinder engine mated to an automatic transmission that returns an EPA estimated 17-mpg in the city and 26-mpg on the highway. The top of the line 2006 Mercedes-Benz S-Class AWD 4MATIC Sedan, priced at $77,250, is powered by a 4.3L, 8-cylinder engine mated to an automatic transmission that returns an EPA estimated 17-mpg in the city and 22-mpg on the highway.