The 2001 Mercedes-Benz S-Class is available as a 4-door, 5-seat sedan. Starting at $78,950, the 2001 Mercedes-Benz S-Class S 500 is powered by a 5.0L , 8 -cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 23-mpg on the highway. The top of the line 2001Mercedes-BenzS-ClassS 55 AMG , priced at $ 98,000 , is powered by a 5.4L , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 22-mpg on the highway.