The 2022 Mercedes-Benz GLE 350 is available as a 4-door, 5-seat sport utility. Starting at $58,650, the 2022 Mercedes-Benz GLE 350 GLE 350 AWD is powered by a 2.0LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway. The top of the line 2022Mercedes-BenzGLE 350GLE 350 4x2 , priced at $ 56,150 , is powered by a 2.0LL , 4 - cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 27-mpg on the highway.