The 2022 Mercedes-Benz E-Class is available as a 4-door, 5-seat sedan. Starting at $57,450, the 2022 Mercedes-Benz E-Class E 350 AWD 4MATIC Sedan is powered by a 2.0LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 29-mpg on the highway. The top of the line 2022Mercedes-BenzE-ClassE 450 AWD 4MATIC Sedan , priced at $ 62,750 , is powered by a 3.0LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 23-mpg in the city and 30-mpg on the highway.
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