The 2021 Mercedes-Benz E-Class is available as a 4-door, 5-seat sedan. Starting at $64,950, the 2021 Mercedes-Benz E-Class E 450 RWD Coupe is powered by a 3.0L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 23-mpg in the city and 31-mpg on the highway. The top of the line 2021 Mercedes-Benz E-Class E 450 AWD 4MATIC All-Terrain Wagon, priced at $67,600, is powered by a 3.0L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 28-mpg on the highway.