The 2010 Mercedes-Benz E-Class is available as a 2-door, 4-seat coupe. Starting at $48,600, the 2010 Mercedes-Benz E-Class E 350 RWD Sedan is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 26-mpg on the highway. The top of the line 2010Mercedes-BenzE-ClassE 350 RWD Coupe , priced at $ 48,050 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 17-mpg in the city and 26-mpg on the highway.