The 2022 Mercedes-Benz CLS 450 is available as a 4-door, 5-seat sedan. Starting at $72,950, the 2022 Mercedes-Benz CLS 450 Base is powered by a 3.0LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 30-mpg on the highway.
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