The 2021 Mercedes-Benz CLS 450 is available as a 4-door, 5-seat sedan. Starting at $70,300, the 2021 Mercedes-Benz CLS 450 CLS 450 Coupe RWD Sedan is powered by a 3.0L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 23-mpg in the city and 30-mpg on the highway. The top of the line 2021Mercedes-BenzCLS 450CLS 450 Coupe AWD 4MATIC , priced at $ 72,800 , is powered by a 3.0L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 29-mpg on the highway.
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