The 2019 Mercedes-Benz CLS 450 is available as a 4-door, 5-seat sedan. Starting at $69,200, the 2019 Mercedes-Benz CLS 450 CLS 450 Coupe RWD Sedan is powered by a 3.0L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 24-mpg in the city and 31-mpg on the highway. The top of the line 2019Mercedes-BenzCLS 450CLS 450 Coupe AWD 4MATIC , priced at $ 71,700 , is powered by a 3.0L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 23-mpg in the city and 30-mpg on the highway.