The 2017 Mercedes-Benz AMG S 65 is available as a 4-door, 5-seat sedan. Starting at $247,900, the 2017 Mercedes-Benz AMG S 65 AMG S 65 RWD Cabriolet is powered by a 6.0L , 12 -cylinder engine mated to an automatic transmission that returns an EPA estimated 14-mpg in the city and 21-mpg on the highway. The top of the line 2017Mercedes-BenzAMG S 65AMG S 65 RWD Coupe , priced at $ 236,250 , is powered by a 6.0L , 12 - cylinder engine mated to an automatic transmission that returns an EPA estimated 13-mpg in the city and 21-mpg on the highway.