The 2021 Lexus RX 450hL is available as a 4-door, 5-seat sport utility. Starting at $51,310, the 2021 Lexus RX 450hL Base is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 29-mpg in the city and 28-mpg on the highway. The top of the line 2021LexusRX 450hLLuxury , priced at $ 57,310 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 29-mpg in the city and 28-mpg on the highway.