The 2018 Lexus RX 450hL is available as a 4-door, 7-seat sport utility. Starting at $50,620, the 2018 Lexus RX 450hL Premium is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 29-mpg in the city and 28-mpg on the highway. The top of the line 2018LexusRX 450hLLuxury , priced at $ 54,555 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 29-mpg in the city and 28-mpg on the highway.