The 2012 Lexus RX 450h is available as a 4-door, 5-seat sport utility. Starting at $45,235, the 2012 Lexus RX 450h FWD is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 32-mpg in the city and 28-mpg on the highway. The top of the line 2012 Lexus RX 450h AWD, priced at $46,825, is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 30-mpg in the city and 28-mpg on the highway.