The 2021 Lexus RX 350 is available as a 4-door, 5-seat sport utility. Starting at $45,220, the 2021 Lexus RX 350 Base FWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 27-mpg on the highway. The top of the line 2021LexusRX 350F SPORT Handling AWD , priced at $ 52,500 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.
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