The 2013 Lexus RX 350 is available as a 4-door, 5-seat sport utility. Starting at $39,660, the 2013 Lexus RX 350 FWD is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 25-mpg on the highway. The top of the line 2013 Lexus RX 350 F Sport (A8) AWD, priced at $47,350, is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 26-mpg on the highway.