The 2012 Lexus RX 350 is available as a 4-door, 5-seat sport utility. Starting at $39,075, the 2012 Lexus RX 350 FWD is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 25-mpg on the highway. The top of the line 2012 Lexus RX 350 AWD, priced at $40,475, is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 24-mpg on the highway.