The 2011 Lexus RX 350 is available as a 4-door, 5-seat sport utility. Starting at $39,075, the 2011 Lexus RX 350 FWD is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 25-mpg on the highway. The top of the line 2011LexusRX 350AWD , priced at $ 40,475 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 24-mpg on the highway.