The 2010 Lexus RX 350 is available as a 4-door, 5-seat sport utility. Starting at $37,625, the 2010 Lexus RX 350 FWD is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 25-mpg on the highway. The top of the line 2010LexusRX 350AWD , priced at $ 39,025 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 24-mpg on the highway.