The 2021 Lexus RC 350 is available as a 2-door, 4-seat coupe. Starting at $45,150, the 2021 Lexus RC 350 Base RWD is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 28-mpg on the highway. The top of the line 2021 Lexus RC 350 F SPORT AWD, priced at $51,230, is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.