The 2021 Lexus LS 500h is available as a 4-door, 5-seat sedan. Starting at $90,500, the 2021 Lexus LS 500h RWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 25-mpg in the city and 33-mpg on the highway. The top of the line 2021LexusLS 500hAWD , priced at $ 93,750 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 23-mpg in the city and 29-mpg on the highway.