The 2020 Lexus LS 500 is available as a 4-door, 5-seat sedan. Starting at $75,450, the 2020 Lexus LS 500 Base RWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 30-mpg on the highway. The top of the line 2020LexusLS 500Inspiration Series AWD , priced at $ 100,865 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 27-mpg on the highway.