The 2022 Lexus IS 350 is available as a 4-door, 5-seat sedan. Starting at $43,550, the 2022 Lexus IS 350 RWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 28-mpg on the highway. The top of the line 2022LexusIS 350AWD , priced at $ 45,550 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.
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