The 2012 Lexus IS 350 is available as a 4-door, 5-seat sedan. Starting at $40,220, the 2012 Lexus IS 350 RWD is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 27-mpg on the highway. The top of the line 2012 Lexus IS 350 AWD, priced at $42,680, is powered by a 3.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 26-mpg on the highway.