The 2020 Lexus IS 300 is available as a 4-door, 5-seat sedan. Starting at $38,560, the 2020 Lexus IS 300 RWD is powered by a 2.0LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 30-mpg on the highway. The top of the line 2020LexusIS 300AWD , priced at $ 41,010 , is powered by a 3.5LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 18-mpg in the city and 24-mpg on the highway.