The 2018 Lexus IS 300 is available as a 4-door, 5-seat sedan. Starting at $38,210, the 2018 Lexus IS 300 RWD is powered by a 2.0L , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 32-mpg on the highway. The top of the line 2018LexusIS 300AWD , priced at $ 40,660 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.