The 2012 Lexus IS 250 is available as a 4-door, 5-seat sedan. Starting at $33,795, the 2012 Lexus IS 250 (M6) RWD is powered by a 2.5L, 6-cylinder engine mated to a manual transmission that returns an EPA estimated 19-mpg in the city and 28-mpg on the highway. The top of the line 2012 Lexus IS 250 AWD, priced at $37,425, is powered by a 2.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 27-mpg on the highway.