The 2011 Lexus IS 250 is available as a 4-door, 5-seat sedan. Starting at $33,295, the 2011 Lexus IS 250 (M6) RWD is powered by a 2.5L , 6 -cylinder engine mated to a manual transmission that returns an EPA estimated 19-mpg in the city and 27-mpg on the highway. The top of the line 2011LexusIS 250AWD , priced at $ 36,925 , is powered by a 2.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 27-mpg on the highway.