The 2009 Lexus IS 250 is available as a 4-door, 5-seat sedan. Starting at $31,305, the 2009 Lexus IS 250 (M6) RWD is powered by a 2.5L, 6-cylinder engine mated to a manual transmission that returns an EPA estimated 18-mpg in the city and 26-mpg on the highway. The top of the line 2009 Lexus IS 250 AWD, priced at $34,935, is powered by a 2.5L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 26-mpg on the highway.