The 2016 Lexus GS 350 is available as a 4-door, 5-seat sedan. Starting at $50,000, the 2016 Lexus GS 350 Base RWD is powered by a 3.5L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 20-mpg in the city and 29-mpg on the highway. The top of the line 2016LexusGS 350AWD , priced at $ 50,470 , is powered by a 3.5L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 19-mpg in the city and 26-mpg on the highway.