The 2006 Lexus GS 300 is available as a 4-door, 5-seat sedan. Starting at $43,150, the 2006 Lexus GS 300 RWD is powered by a 3.0L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 30-mpg on the highway. The top of the line 2006 Lexus GS 300 AWD, priced at $45,100, is powered by a 3.0L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 27-mpg on the highway.