The 2021 Lexus ES 350 is available as a 4-door, 5-seat sedan. Starting at $40,000, the 2021 Lexus ES 350 Base FWD is powered by a 3.5LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 22-mpg in the city and 32-mpg on the highway. The top of the line 2021LexusES 350F SPORT , priced at $ 45,700 , is powered by a , 4 - cylinder engine mated to an automatic transmission that returns an EPA estimated