The 2021 Lexus ES 250 is available as a 4-door, 5-seat sedan. Starting at $40,000, the 2021 Lexus ES 250 Base is powered by a 2.5LL , 4 -cylinder engine mated to an automatic transmission that returns an EPA estimated 25-mpg in the city and 34-mpg on the highway. The top of the line 2021LexusES 250F SPORT , priced at $ 45,800 , is powered by a 2.5LL , 4 - cylinder engine mated to an automatic transmission that returns an EPA estimated 25-mpg in the city and 34-mpg on the highway.