The 2021 Lexus ES 250 is available as a 4-door, 5-seat sedan. Starting at $40,000, the 2021 Lexus ES 250 Base is powered by a 2.5L, 4-cylinder engine mated to an automatic transmission that returns an EPA estimated 25-mpg in the city and 34-mpg on the highway. The top of the line 2021 Lexus ES 250 F SPORT, priced at $45,800, is powered by a 2.5L, 4-cylinder engine mated to an automatic transmission that returns an EPA estimated 25-mpg in the city and 34-mpg on the highway.