The 2000 Jeep Cherokee is available as a 2-door, 5-seat sport utility. Starting at $16,775, the 2000 Jeep Cherokee SE 4x2 2dr is powered by a 2.5LL , 4 -cylinder engine mated to a manual transmission that returns an EPA estimated 20-mpg in the city and 24-mpg on the highway. The top of the line 2000JeepCherokeeRHD Rural Letter Carrier 4x4 4dr , priced at $ 23,630 , is powered by a 4.0LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 20-mpg on the highway.