The 2008 Isuzu Ascender is available as a 4-door, 5-seat sport utility. Starting at $27,149, the 2008 Isuzu Ascender 4x2 is powered by a 4.2L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 14-mpg in the city and 20-mpg on the highway. The top of the line 2008 Isuzu Ascender 4x4, priced at $29,149, is powered by a 4.2L, 6-cylinder engine mated to an automatic transmission that returns an EPA estimated 14-mpg in the city and 20-mpg on the highway.