The 2021 GMC Sierra 3500HD is available as a 2-door, 3-seat regular side. Starting at $38,600, the 2021 GMC Sierra 3500HD Base 4x2 Regular Cab Dual Rear Wheel is powered by a 6.6LL , 8 -cylinder engine mated to an automatic transmission that returns an EPA estimated The top of the line 2021GMCSierra 3500HDDenali 4x4 Crew Cab Short Box , priced at $ 66,700 , is powered by a 6.6LL , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated