The 2022 GMC Sierra 2500HD is available as a 2-door, 3-seat regular side. Starting at $39,200, the 2022 GMC Sierra 2500HD Pro 4x2 Regular Cab is powered by a 6.6LL , 8 -cylinder engine mated to an automatic transmission that returns an EPA estimated The top of the line 2022GMCSierra 2500HDDenali 4x4 Crew Cab 8' Box , priced at $ 68,800 , is powered by a 6.6LL , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated