The 2000 Ford F-150 is available as a 2-door, 3-seat regular side. Starting at $15,520, the 2000 Ford F-150 Work Series 4x2 Regular Cab Styleside Styleside Sh is powered by a 4.2L , 6 -cylinder engine mated to a manual transmission that returns an EPA estimated 16-mpg in the city and 21-mpg on the highway. The top of the line 2000FordF-150SVT Lightning 4x2 Regular Cab Flareside Flareside , priced at $ 30,710 , is powered by a 5.4L , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 13-mpg in the city and 17-mpg on the highway.