The 2012 Ford E-350 Super Duty is available as a 3-door, 2-seat cargo van. Starting at $30,560, the 2012 Ford E-350 Super Duty Commercial Cargo is powered by a 5.4L , 8 -cylinder engine mated to an automatic transmission that returns an EPA estimated 12-mpg in the city and 16-mpg on the highway. The top of the line 2012FordE-350 Super DutyXLT Passenger , priced at $ 35,620 , is powered by a 5.4L , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 11-mpg in the city and 15-mpg on the highway.