The 2001 Ford E-250 is available as a 3-door, 2-seat cargo van. Starting at $21,925, the 2001 Ford E-250 Cargo HD is powered by a 4.2L , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 14-mpg in the city and 19-mpg on the highway. The top of the line 2001FordE-250Extended Cargo , priced at $ 24,290 , is powered by a 4.2L , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 14-mpg in the city and 19-mpg on the highway.